Healthy kidneys clean your blood by removing excess fluid, minerals, and wastes. They also make hormones that keep your bones strong and your blood healthy. But if the kidneys are damaged, they don't work properly. Harmful wastes can build up in your body. Your blood pressure may rise. Your body may retain excess fluid and not make enough red blood cells. This is called kidney failure.

If your kidneys fail, you need treatment to replace the work they normally do. The treatment options are dialysis or a kidney transplant. Each treatment has benefits and drawbacks. No matter which treatment you choose, you'll need to make some changes in your life, including how you eat and plan your activities. But with the help of health care providers, family, and friends, most people with kidney failure can lead full and active lives.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases

You have two kidneys. They are fist-sized organs on either side of your backbone above your waist. Your kidneys filter and clean your blood, taking out waste products and making urine. Kidney tests check to see how well your kidneys are working. They include blood, urine, and imaging tests.

Early kidney disease usually does not have signs or symptoms. Testing is the only way to know how your kidneys are doing. It is important for you to get checked for kidney disease if you have the key risk factors - diabetes, high blood pressure, heart disease, or a family history of kidney failure.

Specific kidney tests include:

• Glomerular filtration rate (GFR) - one of the most common blood tests to check for chronic kidney disease. It tells how well your kidneys are filtering.
• Creatinine blood and urine tests - check the levels of creatinine, a waste product that your kidneys remove from your blood
• Albumin urine test - checks for albumin, a protein that can pass into the urine if the kidneys are damaged
• Imaging tests, such as an ultrasound - provide pictures of the kidneys. The pictures help the health care provider see the size and shape of the kidneys, and check for anything unusual.
• Kidney biopsy - a procedure that involves taking a small piece of kidney tissue for examination with a microscope. It checks for the cause of kidney disease and how damaged your kidneys are.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases

Marijuana is a green, brown, or gray mix of dried, crumbled parts from the marijuana plant. The plant contains chemicals which act on your brain and can change your mood or consciousness.

There are many different ways that people use marijuana, including:

• Rolling it up and smoking it like a cigarette or cigar
• Smoking it in a pipe
• Mixing it in food and eating it
• Brewing it as a tea
• Smoking oils from the plant ("dabbing")
• Using electronic vaporizers ("vaping")

Marijuana can cause both short-term and long-term effects.

Short term:

While you are high, you may experience:

• Altered senses, such as seeing brighter colors
• Altered sense of time, such as minutes seeming like hours
• Changes in mood
• Problems with body movement
• Trouble with thinking, problem-solving, and memory
• Increased appetite

Long term:

In the long term, marijuana can cause health problems, such as:

• Problems with brain development. People who started using marijuana as teenagers may have trouble with thinking, memory, and learning.
• Coughing and breathing problems, if you smoke marijuana frequently
• Problems with child development during and after pregnancy, if a woman smokes marijuana while pregnant

It is possible to overdose on marijuana, if you take a very high dose. Symptoms of an overdose include anxiety, panic, and a rapid heartbeat. In rare cases, an overdose can cause paranoia and hallucinations. There are no reports of people dying from using just marijuana.

After using marijuana for a while, it is possible to get addicted to it. You are more likely to become addicted if you use marijuana every day or you started using it when you were a teenager. If you are addicted, you will have a strong need to take the drug. You may also need to smoke more and more of it to get the same high. When you try to quit, you may have mild withdrawal symptoms such as:

• Irritability
• Trouble sleeping
• Decreased appetite
• Anxiety
• Cravings

The marijuana plant has chemicals that can help with some health problems. More states are making it legal to use the plant as medicine for certain medical conditions. But there isn't enough research to show that the whole plant works to treat or cure these conditions. The U.S. Food and Drug Administration (FDA) has not approved the marijuana plant as a medicine. Marijuana is still illegal at the national level.

However, there have been scientific studies of cannabinoids, the chemicals in marijuana. The two main cannabinoids that are of medical interest are THC and CBD. The FDA has approved two drugs that contain THC. These drugs treat nausea caused by chemotherapy and increase appetite in patients who have severe weight loss from AIDS. There is also a liquid drug that contains CBD. It treats two forms of severe childhood epilepsy. Scientists are doing more research with marijuana and its ingredients to treat many diseases and conditions.

NIH: National Institute on Drug Abuse

Medicines can treat diseases and improve your health. If you are like most people, you need to take medicine at some point in your life. You may need to take medicine every day, or you may only need to take medicine once in a while. Either way, you want to make sure that your medicines are safe, and that they will help you get better. In the United States, the Food and Drug Administration is in charge of ensuring that your prescription and over-the-counter medicines are safe and effective.

There are always risks to taking medicines. It is important to think about these risks before you take a medicine. Even safe medicines can cause unwanted side effects or interactions with food, alcohol, or other medicines you may be taking. Some medicines may not be safe during pregnancy. To reduce the risk of reactions and make sure that you get better, it is important for you to take your medicines correctly. You should also be careful when giving medicines to children, since they can be more vulnerable to the effects of medicines.

Muscle cramps are sudden, involuntary contractions or spasms in one or more of your muscles. They are very common and often occur after exercise. Some people get muscle cramps, especially leg cramps, at night. They can be painful, and they may last a few seconds to several minutes.

You can have a cramp in any muscle, but they happen most often in the:

• Thighs
• Feet
• Hands
• Arms
• Abdomen
• Area along your ribcage

Causes of muscle cramps include:

• Straining or overusing a muscle. This is the most common cause.
• Compression of your nerves, from problems such as a spinal cord injury or a pinched nerve in the neck or back
• Dehydration
• Low levels of electrolytes such as magnesium, potassium, or calcium
• Not enough blood getting to your muscles
• Pregnancy
• Certain medicines
• Getting dialysis

Sometimes the cause of muscle cramps is unknown.

Anyone can get muscle cramps, but they are more common in some people:

• Older adults
• People who are overweight
• Athletes
• Pregnant women
• People with certain medical conditions, such as thyroid and nerve disorders

Muscle cramps are usually harmless, and they go away after a few minutes. But you should contact your health care provider if the cramps:

• Are severe
• Happen frequently
• Don't get better with stretching and drinking enough fluids
• Last a long time
• Are accompanied by swelling, redness, or a feeling of warmth
• Are accompanied by muscle weakness

You usually don't need treatment for muscle cramps. You may be able to find some relief from cramps by:

• Stretching or gently massaging the muscle
• Applying heat when the muscle is tight and ice when the muscle is sore
• Getting more fluids if you are dehydrated

If another medical problem is causing the cramps, treating that problem will likely help. There are medicines that providers sometimes prescribe to prevent cramps, but they are not always effective and may cause side effects. Talk to your provider about the risks and benefits of medicines.

To prevent muscle cramps, you can:

• Stretch your muscles, especially before exercising. If you often get leg cramps at night, stretch your leg muscles before bed.
• Drink plenty of liquids. If you do intense exercise or exercise in the heat, sports drinks can help you replace electrolytes.